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PKA alpha + beta Polyclonal Antibody

View all (7) PKA alpha/beta antibodies

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Product Details

BS-0520R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from bovine PKA.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-alpha-s; alternatively spliced isoform; cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit C alpha; Cbeta2 PKA; Cs-PKA; PKA C-alpha; PKA C-beta; protein kinase A; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase beta-catalytic subunit; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; sperm cAMP-dependent protein kinase catalytic subunit; unnamed protein product

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Gene Aliases: CAFD1; CAFD2; CbPKA; Cs-PKA; PKA C-beta; PKACA; PKACB; PKCA1; PKCD; PPNAD4

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UniProt ID: (Bovine) P00517, (Human) P17612, (Human) P22694, (Bovine) P05131, (Mouse) P05132, (Mouse) P68181, (Rat) P68182

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Entrez Gene ID: (Bovine) 282322, (Human) 5566, (Human) 5567, (Bovine) 282323, (Mouse) 18747, (Rat) 25636, (Mouse) 18749, (Rat) 293508

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity cAMP-dependent protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding protein domain specific binding manganese ion binding ubiquitin protein ligase binding potassium channel inhibitor activity protein kinase A regulatory subunit binding channel activator activity protein serine kinase activity histone H1-4S35 kinase activity small GTPase binding macromolecular complex binding cyclic nucleotide-dependent protein kinase activity non-receptor serine/threonine protein kinase
Process(es)
mesoderm formation neural tube closure mRNA processing protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular response to heat regulation of osteoblast differentiation protein autophosphorylation positive regulation of protein export from nucleus sperm capacitation modulation of synaptic transmission regulation of proteasomal protein catabolic process regulation of protein processing positive regulation of cell cycle arrest cellular response to glucose stimulus cellular response to parathyroid hormone stimulus negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning regulation of bicellular tight junction assembly regulation of heart rate renal water homeostasis chromatin remodeling adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of triglyceride catabolic process regulation of macroautophagy cytokine-mediated signaling pathway cellular potassium ion homeostasis positive regulation of insulin secretion negative regulation of interleukin-2 production high-density lipoprotein particle assembly mitochondrial protein catabolic process insulin secretion involved in cellular response to glucose stimulus positive regulation of cholesterol biosynthetic process positive regulation of gluconeogenesis negative regulation of glycolytic process negative regulation of smoothened signaling pathway positive regulation of phagocytosis positive regulation of calcium-mediated signaling regulation of cell cycle regulation of cardiac muscle contraction regulation of microtubule cytoskeleton organization cellular response to glucagon stimulus cellular response to epinephrine stimulus cell communication by electrical coupling involved in cardiac conduction vascular endothelial cell response to laminar fluid shear stress postsynaptic modulation of chemical synaptic transmission negative regulation of protein localization to chromatin cAMP/PKA signal transduction positive regulation of protein localization to plasma membrane regulation of cardiac conduction negative regulation of TORC1 signaling negative regulation of glycolytic process through fructose-6-phosphate signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cell proliferation cellular response to nutrient levels interleukin-2-mediated signaling pathway TORC1 signaling regulation of cellular respiration spontaneous exocytosis of neurotransmitter negative regulation of meiotic cell cycle regulation of synaptic transmission, glutamatergic cellular response to cold protein localization to lipid particle negative regulation of meiotic cell cycle process involved in oocyte maturation
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