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Active Motif
PKC-B Polyclonal Antibody
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Product Details
61733
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was raised against a peptide within the C-terminal region of human PkC-B.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
Antigen affinity chromatography, Affinity chromatography
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PKC-B; Protein kinase C beta type; protein kinase C, beta 1 polypeptide; unnamed protein product
Gene Aliases: PKC-beta; PKCB; PKCbeta; PKCI(2); PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771
Entrez Gene ID: (Human) 5579
nucleotide binding
chromatin binding
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein kinase C binding
calcium channel regulator activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
histone kinase activity (H3-T6 specific)
histone binding
metal ion binding
androgen receptor binding
protein serine kinase activity
adaptive immune response
immune system process
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
apoptotic process
mitotic nuclear envelope disassembly
signal transduction
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
regulation of glucose transport
negative regulation of glucose transport
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of insulin secretion
intracellular signal transduction
B cell activation
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
B cell receptor signaling pathway
regulation of transport
protein kinase C signaling
cellular response to carbohydrate stimulus
presynaptic modulation of chemical synaptic transmission
regulation of synaptic vesicle exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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