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Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Published species |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PKC zeta Fusion Protein Ag1310 (244-592 aa encoded by BC014270) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: SQGLGLQDF DLIRVIGRGS YAKVLLVRLK KNDQIYAMKV VKKELVHDDE DIDWVQTEKH VFEQASSNPF LVGLHSCFQT TSRLFLVIEY VNGGDLMFHM QRQRKLPEEH ARFYAAEICI ALNFLHERGI IYRDLKLDNV LLDADGHIKL TDYGMCKEGL GPGDTTSTFC GTPNYIAPEI LRGEEYGFSV DWWALGVLMF EMMAGRSPFD IITDNPDMNT EDYLFQVILE KPIRIPRFLS VKASHVLKGF LNKDPKERLG CRPQTGFSDI KSHAFFRSID WDLLEKKQAL PPFQPQITDD YGLDNFDTQF TSEPVQLTPD DEDAIKRIDQ SEFEGFEYIN PLLLSTEESV (244-592 aa encoded by BC014270)
PKC zeta is a member of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms ( alpha, betaI, betaII and gamma) and novel (n) PKC isoforms ( delta, epsilon, zeta, eta and theta). Patterns of expression for each PKC isoform differ among tissues and PKC family member exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC delta and epsilon are independent of Ca2+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: atypical protein kinase C; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, zeta
Gene Aliases: AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-ZETA; PKC2; Pkcz; PRKCZ; R74924; zetaPKC
UniProt ID: (Human) Q05513, (Mouse) Q02956
Entrez Gene ID: (Human) 5590, (Mouse) 18762
Molecular Function:
non-receptor serine/threonine protein kinase
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