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PKD2 Polyclonal Antibody
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Product Details
OSP00017W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse PKD2 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: PKD2.
Target Information
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A MGC138466; MGC138468; Polycystic kidney disease 2 protein homolog; Polycystin 2; Polycystin-2; Transient receptor potential cation channel subfamily P member 2; TRPP1
Gene Aliases: C030034P18Rik; PC2; Pkd2; TRPP2
UniProt ID: (Mouse) O35245
Entrez Gene ID: (Mouse) 18764
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
calcium channel activity
potassium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
channel activity
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
metal ion binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
muscle alpha-actinin binding
alpha-actinin binding
ion channel
kidney development
liver development
embryonic placenta development
heart looping
detection of nodal flow
transport
ion transport
calcium ion transport
cellular calcium ion homeostasis
cell cycle arrest
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
determination of left/right symmetry
heart development
positive regulation of gene expression
regulation of cAMP metabolic process
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
sodium ion transmembrane transport
regulation of cell proliferation
cytoplasmic sequestering of transcription factor
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
detection of mechanical stimulus
release of sequestered calcium ion into cytosol
transmembrane transport
negative regulation of ryanodine-sensitive calcium-release channel activity
placenta blood vessel development
renal tubule morphogenesis
calcium ion transmembrane transport
positive regulation of cell cycle arrest
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
potassium ion transmembrane transport
determination of liver left/right asymmetry
renal system development
regulation of calcium ion import
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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