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Positive control: Rat brain and spleen lysates.
Cellular location: Cytoplasm, Nucleus, Endosome, Cell membrane.
PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PAK-1; Protease-activated kinase 1; Protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase PKN; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine-threonine kinase N; Serine-threonine protein kinase N; serine/threonine kinase 3; serine/threonine protein kinase N; Serine/threonine-protein kinase N1
Gene Aliases: DBK; F730027O18Rik; PAK-1; PAK1; PKN; PKN-ALPHA; PKN1; PRK1; PRKCL1; Stk3
UniProt ID: (Human) Q16512, (Rat) Q63433, (Mouse) P70268
Entrez Gene ID: (Human) 5585, (Rat) 29355, (Mouse) 320795
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