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PKN2 Polyclonal Antibody
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Product Details
BS-0875R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PKN2, amino acids 881-984.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiolipin-activated protein kinase Pak2; p140 kinase; PKN gamma; protease-activated kinase 2; Protein kinase C-like 2; Protein-kinase C-related kinase 2; RP5-905H16.1; serine/threonine kinase 7; Serine/threonine-protein kinase N2; unnamed protein product
Gene Aliases: 6030436C20Rik; AI507382; Pak-2; PAK2; PKN2; PRK2; PRKCL2; PRO2042; STK7
UniProt ID: (Human) Q16513, (Mouse) Q8BWW9
Entrez Gene ID: (Human) 5586, (Mouse) 109333, (Rat) 207122
nucleotide binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
small GTPase binding
histone deacetylase binding
cadherin binding
RNA polymerase binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
poly(A) RNA binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
protein phosphorylation
apoptotic process
cell adhesion
signal transduction
epithelial cell migration
cell projection organization
positive regulation of cytokinesis
intracellular signal transduction
apical junction assembly
positive regulation of viral genome replication
positive regulation of mitotic cell cycle
cell division
vascular endothelial cell response to laminar fluid shear stress
regulation of cell motility
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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