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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene.
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Protein Aliases: Lysophospholipase; Phospholipase A2; Phospholipase B; Phospholipase B/lipase; Phospholipase B1, membrane-associated; PLB/LIP; Triacylglycerol lipase
Gene Aliases: 4632413E21Rik; 4930433E17Rik; 4930539A06Rik; BC033606; hPLB; Phlpb; PLB; PLB/LIP; PLB1
UniProt ID: (Human) Q6P1J6, (Rat) O54728, (Mouse) Q3TTY0
Entrez Gene ID: (Human) 151056, (Rat) 192259, (Mouse) 665270
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