Recommended positive controls: HCT116.
Predicted reactivity: Mouse (84%), Rat (82%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4, 5-bisphosphate to generate the second messengers diacylglycerol and inositol 1, 4, 5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; Phosphoinositide phospholipase C-delta-3; phospholipase C, delta 3; Phospholipase C-delta-3; PLC delta3; PLC-delta-3
Gene Aliases: KIAA1964; PLC-delta-3; PLCD3
UniProt ID: (Human) Q8N3E9
Entrez Gene ID: (Human) 113026
Molecular Function: phospholipase