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Proteintech
PLK5 Polyclonal Antibody
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Product Details
21299-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PLK5 Fusion Protein Ag15881 (1-336 aa encoded by BC100792)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects both PLK5 gene of human and mouse.
Immunogen sequence: MYTVLTGTP PFMASPLSEM YQNIREGHYP EPAHLSANAR RLIVHLLAPN PAERPSLDHL LQDDFFTQGF TPDRLPAHSC HSPPIFAIPP PLGRIFRKVG QRLLTQCRPP CPFTPKEASG PGEGGPDPDS MEWDGESSLS AKEVPCLEGP IHLVAQGTLQ SDLAGPEGSR RPEVEAALRH LQLCLDVGPP ATQDPLGEQQ PILWAPKWVD YSSKYGFGYQ LLDGGRTGRH PHGPATPRRE GTLPTPVPPA GPGLCLLRFL ASEHALLLLF SNGMVQVSFS GVPAQLVLSG EGEGLQLTLW EQGSPGTSYS LDVPQSHGCA PTTGQHLHHA LRMLQSI (1-336 aa encoded by BC100792)
Target Information
Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Inactive serine/threonine-protein kinase PLK5; PLK-5; plk5; Polo-like kinase 5; polo-like kinase 5, pseudogene; serine/threonine-protein kinase PLK5
Gene Aliases: 6330514A18Rik; FG060302; PLK-5; PLK5; PLK5P; SgK384ps
UniProt ID: (Human) Q496M5, (Mouse) Q4FZD7
Entrez Gene ID: (Human) 126520, (Mouse) 216166
defense response to tumor cell
protein phosphorylation
mitotic nuclear division
positive regulation of neuron projection development
G2 DNA damage checkpoint
cell division
cellular response to growth factor stimulus
regulation of G1/S transition of mitotic cell cycle
obsolete transformed cell apoptotic process
cellular response to DNA damage stimulus
cell cycle
negative regulation of cell proliferation
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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