PA3-151 detects proteolipid protein in mouse samples.
PA3-151 has been used successfully in Western blot and immunocytochemistry procedures. By Western blot this antibody detects a ~23-26 kDa proteins representing the proteolipid protein and the splice variant DM20 in adult mouse brain samples.
The PA3-151 immunogen is a synthetic peptide corresponding to the C-terminal residues K(269) L M G R G T K(276) of PLP.
Myelin proteins associated with the central nervous system (CNS) are thought to be unique to the CNS, and play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. The proteolipid protein (PLP) and the splice variant DM20 are the predominant myelin proteins in the CNS. PLP is also one of the most extensively studied myelin proteins because of the prevelance of PLP mutations amongst humans and animals. Such mutations can lead to abnormal myelin formation resulting in conditions such as X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2.
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Protein Aliases: Lipophilin; Myelin proteolipid protein; myelin synthesis deficiency; PLP; Proteolipid Protein; rump shaker
Gene Aliases: DM20; jimpy; jp; msd; Plp; Plp1; rsh
UniProt ID: (Mouse) P60202
Entrez Gene ID: (Mouse) 18823