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Invitrogen
PLSCR2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104018
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PLSCR2(Accession Q9NRY7), corresponding to amino acid residues A185-I235.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PLSCR2.
Target Information
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.; FUNCTION: Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ca(2+)-dependent phospholipid scramblase 2; phospholipid flip/flop enzyme; PL scramblase 2; unnamed protein product
UniProt ID: (Human) Q9NRY7, (Mouse) Q9DCW2
Entrez Gene ID: (Human) 57047, (Mouse) 18828
calcium ion binding
protein binding
phospholipid scramblase activity
magnesium ion binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
virus receptor activity
nuclease activity
epidermal growth factor receptor binding
zinc ion binding
SH3 domain binding
enzyme binding
lead ion binding
CD4 receptor binding
mercury ion binding
immune response
phospholipid scrambling
regulation of mast cell activation
positive regulation of innate immune response
positive regulation of transcription from RNA polymerase II promoter
viral entry into host cell
regulation of Fc receptor mediated stimulatory signaling pathway
phosphatidylserine exposure on apoptotic cell surface
cellular response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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