Immunogen sequence: TLLTRQPAPL SQKQRSFVTF RGEPAEGFNH LVVDERTGHI YLGAVNRIYK LSSDLKVLVT HETGPDEDNP KCYPPRIVQT CNEPLTTTNN VNKMLLIDYK ENRLIACGSL YQGICKLLRL EDLFKLGEPY HKKEHYLSGV NESGSVFGVI VSYSNLDDKL FIATAVDGKP EYFPTISSRK LTKNSEADGM FAYVFHD; Positive Samples: Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein
PLXNA4 is a protein coding gene. Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
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Protein Aliases: Plexin-A4
Gene Aliases: 9330117B14; Kiaa1550; mKIAA1550; Plxa4; Plxna4
UniProt ID: (Mouse) Q80UG2