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Invitrogen
PLXNB2 Polyclonal Antibody
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PLXNB2 Antibody (PA5-47721) in IHC (P)
Immunohistochemical analysis of PLXNB2 in immersion fixed paraffin-embedded sections of human colon cancer. Samples were incubated in PLXNB2 polyclonal antibody (Product # PA5-47721) using a dilution of 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-basic. Tissue was stained with the Anti-Sheep HRP... View More
Product Details
PA5-47721
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human Plexin B2 Leu20-Arg1160
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) Plexin A1, rmPlexin A2, recombinant human (rh) Plexin A4, rhPlexin B1, rhPlexin B3, rhPlexin C1 and rhPlexin D1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Plexin-B2 is a member of the Semaphorin receptor family. The semaphorin family consists of membrane and secreted proteins involved in attraction and repulsion of neuronal guidance cues. Plexin-B1 is a transmembrane protein that can be cleaved converting the single chain precursor into a heterodimeric receptor. It has been shown to bind Sema4D/CD100 and is involved in axon development in mouse embryos. Sema4D also plays a role in the immune system interacting with CD72. Plexin-B2's possible role in the immune system has not been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MM1; MM1KIAA0315dJ402G11.3; Plexin-B2
Gene Aliases: dJ402G11.3; KIAA0315; MM1; Nbla00445; PLEXB2; PLXNB2
UniProt ID: (Human) O15031
Entrez Gene ID: (Human) 23654
neural tube closure
regulation of protein phosphorylation
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell adhesion
neuroblast proliferation
brain development
regulation of cell shape
positive regulation of neuron projection development
regulation of cell migration
regulation of GTPase activity
positive regulation of axonogenesis
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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