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Invitrogen
PLXNB2 Polyclonal Antibody
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PLXNB2 Antibody (PA5-47880) in IHC (P)
Immunohistochemical analysis of PLXNB2 in immersion fixed frozen sections of mouse embryo. Samples were incubated with PLXNB2 Polyclonal Antibody (Product # PA5-47880) using a dilution of 0.6 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Sheep IgG HRP Secondary Antibody. Tissue was stained with DAB (brown) and counterstained with hematoxylin (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47880
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse,
Zebrafish
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse Plexin B2 Leu20-Trp1029
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 9% cross-reactivity with recombinant human Plexin B2 is observed, and less than 1% cross-reactivity with recombinant mouse Plexin B3 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Plexin-B2 is a member of the Semaphorin receptor family. The semaphorin family consists of membrane and secreted proteins involved in attraction and repulsion of neuronal guidance cues. Plexin-B1 is a transmembrane protein that can be cleaved converting the single chain precursor into a heterodimeric receptor. It has been shown to bind Sema4D/CD100 and is involved in axon development in mouse embryos. Sema4D also plays a role in the immune system interacting with CD72. Plexin-B2's possible role in the immune system has not been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: differentially expressed in brain tumors; MM1KIAA0315dJ402G11.3; unnamed protein product
Gene Aliases: Debt; plexin-B2
UniProt ID: (Mouse) B2RXS4
Entrez Gene ID: (Mouse) 140570
neural tube closure
regulation of protein phosphorylation
cytoplasmic translation
receptor-mediated endocytosis
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell adhesion
neuroblast proliferation
synapse assembly
brain development
regulation of cell shape
regulation of neuron projection development
positive regulation of neuron projection development
regulation of cell migration
positive regulation of cell projection organization
negative regulation of translation in response to stress
cellular response to stress
tRNA stabilization
regulation of GTPase activity
positive regulation of translation
positive regulation of axonogenesis
regulation of protein metabolic process
semaphorin-plexin signaling pathway
excitatory synapse assembly
regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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