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Invitrogen

PMCA ATPase Polyclonal Antibody

1 Reference
View all (4) PMCA ATPase antibodies

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PMCA ATPase Polyclonal Antibody

Product Details

PA5-107073

Applications
Tested Dilution
Publications

Western Blot (WB)

0.2-1 µg/mL
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the middle region of human ATP2B4 (aa 936-985)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

50 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.4, with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817789

Product Specific Information

Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Immunogen sequence: FAGEKFFDID SGRKAPLHSP PSQHYTIVFN TFVLMQLFNE INSRKIHGEK

Target Information

The calcium pump of the plasma membrane (PMCA ATPase) pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the sarcoplasmic and endoplasmic reticulum calcium (SERCA) ATPase and the sodium/potassium pump. Studies indicate that there are four known isoforms of the PMCA ATPase which are encoded by a multigene family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ATPase, Ca++ transporting, plasma membrane 1; ATPase, Ca++ transporting, plasma membrane 2; ATPase, Ca++ transporting, plasma membrane 3; ATPase, Ca++ transporting, plasma membrane 4; calcium pump; cilia and flagella associated protein 39; Matrix-remodeling-associated protein 1; plasma membrane Ca(2+)-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; Plasma membrane calcium pump isoform 2; Plasma membrane calcium pump isoform 3; Plasma membrane calcium pump isoform 4; plasma membrane calcium-ATPase isoform 1 alternative splice variant k at splice site B and splice variant b at splice site C; plasma membrane calcium-ATPase isoform 2 alternative splice variant a at splice site C; plasma membrane calcium-ATPase isoform 2, splice variant i; plasma membrane calcium-ATPase isoform 3, splice variant a at alternative splice site C; plasma membrane calcium-ATPase isoform 4 alternative splice variant x at splice site A; plasma membrane calcium-ATPase isoform 4, splice variant b at alternative splice site C; Plasma membrane calcium-transporting ATPase 1; Plasma membrane calcium-transporting ATPase 2; Plasma membrane calcium-transporting ATPase 3; Plasma membrane calcium-transporting ATPase 4; PMCA1; PMCA2; PMCA3; PMCA4; sarcolemmal calcium pump; unnamed protein product

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Gene Aliases: ATP2B1; ATP2B2; ATP2B3; ATP2B4; CFAP39; CLA2; DFNA82; MRD66; MXRA1; OPCA; PMCA1; PMCA1kb; PMCA2; PMCA2a; PMCA2i; PMCA3; PMCA3a; PMCA4; PMCA4b; PMCA4x; SCAX1

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UniProt ID: (Human) P20020, (Human) Q01814, (Human) Q16720, (Human) P23634

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Entrez Gene ID: (Human) 490, (Human) 491, (Human) 492, (Human) 493

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Function(s)
nucleotide binding calcium-transporting ATPase activity protein binding calmodulin binding ATP binding calcium ion transmembrane transporter activity ATPase activity metal ion binding molecular function inhibitor activity calcium ion binding PDZ domain binding P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration sodium channel regulator activity protein kinase binding protein phosphatase 2B binding nitric-oxide synthase inhibitor activity nitric-oxide synthase binding scaffold protein binding
Process(es)
neural retina development regulation of transcription from RNA polymerase II promoter ion transport calcium ion transport cellular calcium ion homeostasis spermatogenesis negative regulation of gene expression urinary bladder smooth muscle contraction negative regulation of angiogenesis hippocampus development sperm motility ion transmembrane transport nitric oxide-cGMP-mediated signaling pathway negative regulation of blood vessel endothelial cell migration negative regulation of nitric oxide biosynthetic process regulation of cytosolic calcium ion concentration response to hydrostatic pressure calcium ion transmembrane transport negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus negative regulation of adrenergic receptor signaling pathway calcium ion transmembrane import into cytosol calcium ion import across plasma membrane negative regulation of the force of heart contraction transport across blood-brain barrier negative regulation of arginine catabolic process calcium ion export regulation of sodium ion transmembrane transport negative regulation of cellular response to vascular endothelial growth factor stimulus regulation of cell cycle G1/S phase transition positive regulation of protein localization to plasma membrane negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process regulation of cardiac conduction cellular response to acetylcholine negative regulation of cytokine production regulation of vascular smooth muscle contraction regulation of blood pressure positive regulation of bone mineralization negative regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport regulation of cellular response to insulin stimulus calcium ion export from cell sensory perception of sound neuron differentiation regulation of postsynaptic cytosolic calcium ion concentration regulation of presynaptic cytosolic calcium ion concentration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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