Search
Proteintech
PNKP Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
13558-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PNKP Fusion Protein Ag4421 (171-521 aa encoded by BC033822)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLDGTLITT RSGKVFPTGP SDWRILYPEI PRKLRELEAE GYKLVIFTNQ MSIGRGKLPA EEFKAKVEAV VEKLGVPFQV LVATHAGLYR KPVTGMWDHL QEQANDGTPI SIGDSIFVGD AAGRPANWAP GRKKKDFSCA DRLFALNLGL PFATPEEFFL KWPAAGFELP AFDPRTVSRS GPLCLPESRA LLSASPEVVV AVGFPGAGKS TFLKKHLVSA GYVHVNRDTL GSWQRCVTTC ETALKQGKRV AIDNTNPDAA SRARYVQCAR AAGVPCRCFL FTATLEQARH NNRFREMTDS SHIPVSDMVM YGYRKQFEAP TLAEGFSAIL EIPFRLWVEP RLGRLYCQFS EG (171-521 aa encoded by BC033822)
Target Information
Anti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5'-hydroxy and 3'-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-beta and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Bifunctional polynucleotide phosphatase/kinase; differentially expressed in malignancies; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); phosphatase/kinase; PKNP; polynucleotide kinase; Polynucleotide kinase-3'-phosphatase
Gene Aliases: 1810009G08Rik; AOA4; CMT2B2; EIEE10; MCSZ; PNK; PNKP
UniProt ID: (Human) Q96T60
Entrez Gene ID: (Human) 11284, (Mouse) 59047, (Rat) 308576
nucleotide binding
damaged DNA binding
double-stranded DNA binding
catalytic activity
endonuclease activity
protein binding
ATP binding
kinase activity
transferase activity
hydrolase activity
purine nucleotide binding
polynucleotide 3'-phosphatase activity
ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
ATP-dependent polynucleotide kinase activity
nucleotide kinase activity
molecular_function
DNA-dependent DNA replication
DNA repair
base-excision repair, gap-filling
nucleotide-excision repair
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
response to oxidative stress
response to radiation
positive regulation of telomere maintenance
positive regulation of double-strand break repair via nonhomologous end joining
metabolic process
phosphorylation
dephosphorylation
DNA damage response, detection of DNA damage
nucleotide phosphorylation
DNA 3' dephosphorylation involved in DNA repair
polynucleotide 3' dephosphorylation
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support