Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
POLI Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
13635-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
POLI Fusion Protein Ag4563 (1-340 aa encoded by BC032662)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MELADVGAA ASSQGVHDQV LPTPNASSRV IVHVDLDCFY AQVEMISNPE LKDKPLGVQQ KYLVVTCNYE ARKLGVKKLM NVRDAKEKCP QLVLVNGEDL TRYREMSYKV TELLEEFSPV VERLGFDENF VDLTEMVEKR LQQLQSDELS AVTVSGHVYN NQSINLLDVL HIRLLVGSQI AAEMREAMYN QLGLTGCAGV ASNKLLAKLV SGVFKPNQQT VLLPESCQHL IHSLNHIKEI PGIGYKTAKC LEALGINSVR DLQTFSPKIL EKELGISVAQ RIQKLSFGED NSPVILSGPP QSFSEEDSFK KCSSEVEAKN KIEELLASLL NRVCQDGRKP H (1-340 aa encoded by BC032662)
Target Information
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA polymerase iota; Eta2; polymerase (DNA directed) iota; polymerase (DNA) iota; polymerase (DNA-directed), iota; RAD 30B; RAD30; RAD30 homolog B
Gene Aliases: POLI; RAD30B; RAD3OB
UniProt ID: (Human) Q9UNA4, (Mouse) Q6R3M4
Entrez Gene ID: (Human) 11201, (Mouse) 26447, (Rat) 291526
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support