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Rockland
POLR3F Polyclonal Antibody
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FIGURE: 1 / 3
POLR3F Antibody (600-401-DR2) in ICC/IF
Immunofluorescence Microscopy of POLR3F antibody. Tissue: Human brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: POLR3F antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: POLR3F as red fluorescent signal.
Product Details
600-401-DR2
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-POLR3F antibody was prepared from whole rabbit serum produced by repeated immunizations with a 21 amino acid synthetic peptide from near the N-terminus of human POLR3F.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The human POLR3F is a component of RNA III polymerase. RNA polymerase III transcribes many essential, small, noncoding RNAs, including the 5S rRNAs and tRNAs. While most pol III-transcribed genes are found scattered throughout the linear chromosome maps or in multiple linear clusters, there is increasing evidence that many of these genes prefer to be spatially clustered, often at or near the nucleolus. This association could create an environment that fosters the coregulation of transcription by pol III with transcription of the large ribosomal RNA repeats by RNA polymerase I (pol I) within the nucleolus. Given the high number of pol III-transcribed genes in all eukaryotic genomes, the spatial organization of these genes is likely to affect a large portion of the other genes in a genome. POLR3F has also been recently identified as an HIV dependency factor (HDF), suggesting that POLR3F may be an important drug target in HIV treatment. At least two isoforms of POLR3F are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-directed RNA polymerase III subunit F; DNA-directed RNA polymerase III subunit RPC6; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; polymerase (RNA) III subunit F; RNA polymerase III 39 kDa subunit; RNA polymerase III C39 subunit; RNA polymerase III subunit C6; RPC39
Gene Aliases: 2810411G20Rik; 3010019O03Rik; 3110032A07Rik; POLR3F; RPC39; RPC6
UniProt ID: (Human) Q9H1D9, (Mouse) Q921X6
Entrez Gene ID: (Human) 10621, (Mouse) 70408, (Rat) 311487
regulation of transcription from RNA polymerase III promoter
transcription from RNA polymerase III promoter
positive regulation of type I interferon production
positive regulation of interferon-beta production
innate immune response
positive regulation of innate immune response
defense response to virus
immune system process
transcription, DNA-templated
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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