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Invitrogen
PP1 alpha Polyclonal Antibody
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Product Details
PA5-17825
Product Specifications
Species Reactivity
Mouse,
Non-human primate,
Rat,
Fruit fly,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the amino-terminal sequence of human PP1alpha
Conjugate
Form
Liquid
Concentration
92 µg/mL
Amount
9.2 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with PP1-delta or PP1-gamma.
Target Information
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG6593-PA; CG6593-PB; GADD34; LD14639p; MGC15877; MGC1674; PP-1A; Pp1alpha-96A-PA; Pp1alpha-96A-PB; protein phosphatase 1; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase I alpha subunit (PPPIA) (EC 3.1.3.16); Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1d; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine-protein phosphatase alpha-1 isoform; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; testicular tissue protein Li 155; unnamed protein product
Gene Aliases: 96A; CG6593; dism2; Dmel\CG6593; Dmel_CG6593; DmPp1-96A; PP-1A; PP1; PP1 96A; PP1 alpha96a; Pp1-96A; PP1A; PP1A-96A; PP1alpha; PP1alpha-96A; PP1alpha96A; PP1alpha[[1]]; PP1c; PP1c 96A; PPP1A; Ppp1c; PPP1CA
UniProt ID: (Human) P62136, (Fruit fly) P48461, (Mouse) P62137, (Rat) P62138
Entrez Gene ID: (Human) 5499, (Fruit fly) 42922, (Mouse) 19045, (Rat) 24668
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
iron ion binding
protein binding
protein phosphatase 1 binding
hydrolase activity
phosphatase activity
ribonucleoprotein complex binding
macromolecular complex binding
metal ion binding
transition metal ion binding
cadherin binding involved in cell-cell adhesion
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
protein complex binding
protein phosphatase
telomere maintenance
promoter clearance from RNA polymerase II promoter
glycogen metabolic process
regulation of glycogen biosynthetic process
regulation of glycogen catabolic process
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein dephosphorylation
response to lead ion
dephosphorylation
lung development
circadian regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
telomere maintenance in response to DNA damage
regulation of translational initiation in response to stress
positive regulation of glycogen biosynthetic process
branching morphogenesis of an epithelial tube
protein stabilization
cell division
regulation of canonical Wnt signaling pathway
double-strand break repair via alternative nonhomologous end joining
cell-cell adhesion
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of innate immune response
negative regulation of smoothened signaling pathway
defense response to Gram-negative bacterium
positive regulation of canonical Wnt signaling pathway
beta-catenin destruction complex disassembly
carbohydrate metabolic process
regulation of translation
cell cycle
female meiotic division
cellular process
rhythmic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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