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Invitrogen

PP2A alpha/beta Polyclonal Antibody

View all (12) PP2A alpha/beta antibodies

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PP2A alpha/beta Polyclonal Antibody

Product Details

PA5-106938

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PPP2CA(Accession P67775), corresponding to amino acid residues T281-L309.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854602

Product Specific Information

Antibody detects endogenous levels of total PP2A-C alpha/beta.

Target Information

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: phosphatase 2A; PP2A-alpha; PP2A-beta; PPP2CA; PPP2CB; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; protein phosphatase-2A-alpha; protein phosphatase-2A-beta; Replication protein C; RP C; RP-C; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146; unnamed protein product

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Gene Aliases: AI115466; D8Ertd766e; HJS3; NEDLBA; PP2A; Pp2a1; Pp2a2; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; PPP2CA; PPP2CB; R75353; RP-C

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UniProt ID: (Human) P67775, (Human) P62714, (Mouse) P63330, (Rat) P63331, (Rat) P62716, (Mouse) P62715

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Entrez Gene ID: (Human) 5515, (Human) 5516, (Mouse) 19052, (Rat) 24672, (Rat) 24673, (Mouse) 19053

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Function(s)
phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding hydrolase activity metal ion binding protein heterodimerization activity tau protein binding GABA receptor binding RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity ion channel binding protein C-terminus binding enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding protein complex binding protein kinase B binding protein dimerization activity protein phosphatase 2A binding protein antigen binding protein phosphatase
Process(es)
mitotic cell cycle regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter protein dephosphorylation mesoderm development response to lead ion negative regulation of epithelial to mesenchymal transition regulation of microtubule polymerization negative regulation of hippo signaling intracellular signal transduction peptidyl-threonine dephosphorylation regulation of growth T cell homeostasis regulation of cell differentiation meiotic cell cycle negative regulation of protein kinase B signaling negative regulation of canonical Wnt signaling pathway vascular endothelial cell response to oscillatory fluid shear stress RNA polymerase II transcription initiation surveillance positive regulation of NLRP3 inflammasome complex assembly negative regulation of glycolytic process through fructose-6-phosphate regulation of G1/S transition of mitotic cell cycle apoptotic mitochondrial changes regulation of gene expression negative regulation of gene expression negative regulation of tumor necrosis factor-mediated signaling pathway response to endoplasmic reticulum stress response to hydrogen peroxide negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Ras protein signal transduction response to antibiotic regulation of neurofibrillary tangle assembly negative regulation of transcription from RNA polymerase II promoter regulation of protein phosphorylation negative regulation of protein phosphorylation regulation of receptor activity regulation of protein autophosphorylation positive regulation of protein phosphatase type 2A activity positive regulation of protein dephosphorylation regulation of protein catabolic process negative regulation of transcription factor import into nucleus positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cell cycle protein heterotrimerization cellular response to glucose stimulus positive regulation of protein serine/threonine kinase activity negative regulation of calcium ion transmembrane transporter activity cardiac ventricle development heart development cellular response to insulin stimulus cellular response to calcium ion cellular response to cytokine stimulus cellular response to ethanol cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus
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