Search
Invitrogen
PPAR alpha Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-85125
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Insect,
Mouse,
Plant,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human PPAR alpha. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.44 mg/mL
Amount
144 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (91%), Rat (88%), Dog (92%), Pig (92%), Rhesus Monkey (98%), Bovine (88%), Guinea pig (87%).
Positive Control: Rat primary hepatocyte, mouse liver, mouse brain, mouse lung.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator; peroxisome proliferator activated receptor; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; PPARA; PPARalpha; unnamed protein product
Gene Aliases: 4933429D07Rik; AW742785; hPPAR; NR1C1; PPAR; PPAR-alpha; PPARA; PPARalpha
UniProt ID: (Human) Q07869, (Rat) P37230, (Mouse) P23204
Entrez Gene ID: (Human) 5465, (Rat) 25747, (Mouse) 19013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
lipid binding
phosphatase binding
protein domain specific binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin conjugating enzyme binding
signaling receptor activity
sequence-specific DNA binding
macromolecular complex binding
metal ion binding
NFAT protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
MDM2/MDM4 family protein binding
DNA-binding transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
receptor activity
drug binding
protein complex binding
protein heterodimerization activity
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
gluconeogenesis
regulation of transcription, DNA-templated
lipid metabolic process
fatty acid metabolic process
heart development
response to nutrient
lactation
epidermis development
cellular response to starvation
hormone-mediated signaling pathway
gene expression
regulation of gene expression
regulation of cellular ketone metabolic process
negative regulation of macrophage derived foam cell differentiation
negative regulation of cholesterol storage
regulation of fatty acid metabolic process
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
positive regulation of fatty acid beta-oxidation
negative regulation of appetite
response to insulin
circadian regulation of gene expression
behavioral response to nicotine
peroxisome proliferator activated receptor signaling pathway
wound healing
lipoprotein metabolic process
regulation of circadian rhythm
response to ethanol
positive regulation of gluconeogenesis
negative regulation of blood pressure
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of fatty acid metabolic process
positive regulation of transcription from RNA polymerase II promoter
nitric oxide metabolic process
positive regulation of fatty acid oxidation
positive regulation of lipid biosynthetic process
rhythmic process
negative regulation of inflammatory response
negative regulation of protein kinase B signaling
negative regulation of cell growth involved in cardiac muscle cell development
enamel mineralization
cellular response to fructose stimulus
negative regulation of cytokine production involved in inflammatory response
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of leukocyte cell-cell adhesion
negative regulation of reactive oxygen species biosynthetic process
negative regulation of hepatocyte apoptotic process
positive regulation of transformation of host cell by virus
regulation of fatty acid transport
positive regulation of ATP biosynthetic process
transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of receptor biosynthetic process
negative regulation of sequestering of triglyceride
negative regulation of protein binding
steroid hormone mediated signaling pathway
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
negative regulation of neuron death
negative regulation of transcription regulatory region DNA binding
glucose metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support