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Invitrogen
PPP2R1A Polyclonal Antibody
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Product Details
PA5-17516
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the carboxy terminus of human PP2A A subunit
Conjugate
Form
Liquid
Concentration
33 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PP2A subunits.
Target Information
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 65 kDa regulatory subunit of protein phosphatase; alpha isoform of regulatory subunit A, protein phosphatase 2; CG17291-PA; CG17291-PB; CG17291-PC; CG17291-PD; CG17291-PE; Medium tumor antigen-associated 61 kDa protein; MGC786; PP2A 65kD subunit A; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; Pp2A-29B-PA; Pp2A-29B-PB; Pp2A-29B-PC; Pp2A-29B-PD; Pp2A-29B-PE; PP2Ac; PP2CA; PP2Calpha; PR65; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; protein phosphatase 2 regulatory subunit A, alpha; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase 2A; protein phosphatase PP2A; Protein phosphatase PP2A regulatory subunit A; protein phosphate 2A; regulatory subunit A of type 2A protein phosphatase; RP-C; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform; serine/threonine protein phosphatase A subunit type 2A; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; testicular secretory protein Li 1
Gene Aliases: 29B; 6330556D22Rik; A/PR65; CG13383; CG17291; CG33297; Dmel\CG17291; Dmel_CG17291; dPP2A A; DPR65; MRD36; PP2A; PP2A 29B; PP2A A; PP2A-29B; PP2A-A; PP2A-Aalpha; Pp2A29B; PP2A[A]; PP2AAALPHA; PPP2R1A; PR65; PR65A
UniProt ID: (Human) P30153, (Fruit fly) P36179, (Mouse) Q76MZ3
Entrez Gene ID: (Human) 5518, (Fruit fly) 2768940, (Mouse) 51792, (Rat) 117281
G2/M transition of mitotic cell cycle
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
inactivation of MAPK activity
regulation of DNA replication
regulation of transcription, DNA-templated
protein complex assembly
protein dephosphorylation
ceramide metabolic process
apoptotic process
chromosome segregation
mitotic nuclear envelope reassembly
female meiotic division
RNA splicing
response to organic substance
second-messenger-mediated signaling
regulation of Wnt signaling pathway
regulation of cell adhesion
negative regulation of cell growth
regulation of protein phosphatase type 2A activity
regulation of growth
negative regulation of tyrosine phosphorylation of Stat3 protein
regulation of cell differentiation
meiotic spindle elongation
mitotic sister chromatid separation
meiotic sister chromatid cohesion, centromeric
peptidyl-serine dephosphorylation
regulation of meiotic cell cycle process involved in oocyte maturation
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
autophagy
centrosome cycle
centriole replication
negative regulation of hippo signaling
negative regulation of smoothened signaling pathway
negative regulation of insulin receptor signaling pathway
spindle assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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