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Invitrogen
PPP2R4 Polyclonal Antibody
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FIGURE: 1 / 7
PPP2R4 Antibody (PA5-106900) in IHC (P)
Immunohistochemistry analysis of PPP2R4 in human prostate cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PPP2R4 polyclonal antibody (Product # PA5-106900) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTPA(Accession Q15257), corresponding to amino acid residues I327-G358.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PPP2R4.
Target Information
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC2184; OTTHUMP00000022333; Phosphotyrosyl phosphatase activator; PP2A phosphatase activator; PP2A subunit B' isoform PR53; PP2A, subunit B', PR53 isoform; protein phosphatase 2 regulatory subunit 4; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A regulatory subunit 4; protein phosphatase 2A, regulatory subunit B (PR 53); protein phosphatase 2A, regulatory subunit B' (PR 53); PTPA; Serine/threonine-protein phosphatase 2A activator; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B'
Gene Aliases: 2610042B21Rik; C77440; N28142; PP2A; PPP2R4; PR53; PTPA
UniProt ID: (Human) Q15257, (Mouse) P58389
Entrez Gene ID: (Human) 5524, (Rat) 362102, (Mouse) 110854
peptidyl-prolyl cis-trans isomerase activity
receptor binding
protein binding
ATP binding
protein tyrosine phosphatase activator activity
protein phosphatase type 2A regulator activity
ATPase activity
protein homodimerization activity
protein heterodimerization activity
protein phosphatase 2A binding
nucleotide binding
isomerase activity
phosphatase activator activity
protein-binding activity modulator
phosphatase activator
phosphatase modulator
protein peptidyl-prolyl isomerization
mitotic spindle organization in nucleus
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
negative regulation of protein dephosphorylation
positive regulation of apoptotic process
regulation of phosphoprotein phosphatase activity
metabolic process
positive regulation of catalytic activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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