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Product Details
PA5-22148
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 228 of PPP3CB (Uniprot ID#P16298)
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11157233
Product Specific Information
Recommended positive controls: HeLa, Molt-4, mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (83%), Xenopus laevis (83%), Rabbit (99%), Chicken (96%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PPP3CB is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcineurin A beta; calcineurin A2; Calmodulin-dependent calcineurin A subunit beta isoform; CAM-PRP catalytic subunit; CNA beta; PP2BA beta; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase from PCR fragment H32; RP11-345K20.1; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Gene Aliases: 1110063J16Rik; CALNA2; CALNB; CNA2; Cnab; CnAbeta; PP2Bbeta; PPP3CB
UniProt ID: (Human) P16298, (Mouse) P48453
Entrez Gene ID: (Human) 5532, (Mouse) 19056
Molecular Function:
protein phosphatase
negative regulation of T cell mediated cytotoxicity
lymphangiogenesis
protein phosphorylation
protein dephosphorylation
signal transduction
Wnt signaling pathway, calcium modulating pathway
heart development
learning
memory
dephosphorylation
calcium ion regulated exocytosis
T cell differentiation
locomotion involved in locomotory behavior
calcineurin-NFAT signaling cascade
response to cytokine
social behavior
cellular response to drug
positive regulation of insulin secretion involved in cellular response to glucose stimulus
Fc-epsilon receptor signaling pathway
T cell proliferation
T cell activation
T cell homeostasis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
axon extension
regulation of insulin secretion
positive regulation of NFAT protein import into nucleus
response to stress
regulation of gene expression
protein serine/threonine phosphatase activity
calcium ion binding
protein binding
calmodulin binding
drug binding
enzyme binding
protein phosphatase 2B binding
calmodulin-dependent protein phosphatase activity
protein dimerization activity
phosphoprotein phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity
hydrolase activity
metal ion binding
protein heterodimerization activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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