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Invitrogen
PR3 Monoclonal Antibody (PR3G-2)
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Product Details
MA1-40218
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
PR3G-2
Immunogen
Crude alpha granule extract.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-40218 detects Proteinase 3 from human samples.
MA1-40218 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), and Western blot applications.
The MA1-40218 immunogen is human PR3.
Endotoxin <24 EU/mg.
Target Information
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGP7; azurophil granule protein 7; C-ANCA antigen; Leukocyte proteinase 3; Myeloblastin; Neutrophil proteinase 4; NP-4; P29; PR-3; serine proteinase, neutrophil; unnamed protein product; Wegener autoantigen; Wegener granulomatosis autoantigen
Gene Aliases: ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; PRTN3
UniProt ID: (Human) P24158
Entrez Gene ID: (Human) 5657
proteolysis
membrane protein ectodomain proteolysis
positive regulation of cell proliferation
antimicrobial humoral response
collagen catabolic process
positive regulation of GTPase activity
cell-cell junction maintenance
negative regulation of phagocytosis
neutrophil extravasation
mature conventional dendritic cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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