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Invitrogen

PRDM16 Polyclonal Antibody

3 Published Figures
2 References
View all (10) PRDM16 antibodies

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PRDM16 Polyclonal Antibody

Product Details

720206

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptides corresponding to human PRDM16/MEL1 (236-251, 23-40)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2-7.4, with 30% glycerol, 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2664823

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, Dog

Target Information

PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: line 27; MDS1/EVI1-like gene 1; PR domain 16; PR domain containing 16; PR domain zinc finger protein 16; PR domain zinc finger protein 16-like; PR domain-containing protein 16; PRDM16; PFM13; transcription factor MEL1; unnamed protein product

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Gene Aliases: 5730557K01Rik; CMD1LL; csp1; KMT8F; LVNC8; MEL1; PFM13

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UniProt ID: (Human) Q9HAZ2, (Mouse) A2A935

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Entrez Gene ID: (Human) 63976, (Rat) 100366024, (Mouse) 70673

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity transcription coactivator activity transcription corepressor activity protein binding sequence-specific DNA binding histone methyltransferase activity (H3-K9 specific) DNA-binding transcription factor binding chromatin-protein adaptor activity histone H3 methyltransferase activity histone H3K9 monomethyltransferase activity SMAD binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter immune system process tolerance induction in gut-associated lymphoid tissue chromatin remodeling regulation of transcription from RNA polymerase II promoter biological_process stem cell population maintenance neurogenesis hemopoiesis negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of granulocyte differentiation somatic stem cell population maintenance regulation of cellular respiration tongue development regulatory T cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter white fat cell differentiation brown fat cell differentiation negative regulation of muscle cell differentiation protein maturation palate development heterochromatin organization protein localization to chromatin positive regulation of brown fat cell differentiation maintenance of cell number positive regulation of cold-induced thermogenesis beige fat cell differentiation negative regulation of white fat cell differentiation
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