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Invitrogen
PRDM2 Polyclonal Antibody
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FIGURE: 1 / 9
PRDM2 Antibody (PA5-115792) in IHC (P)
Immunohistochemistry analysis of PRDM2 in mouse colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115792) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115792
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRDM2(Accession Q13029), corresponding to amino acid residues W139-Q189.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PRDM2.
Target Information
PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G3b; GATA-3 binding protein G3B; GATA-3-binding protein G3B; Lysine N-methyltransferase 8; MTB-ZF; MTBzf; MTE-binding protein; PR domain 2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; retinoblastoma interacting zinc finger protein; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; RP5-1177E19.1; unnamed protein product; Zinc finger protein RIZ; zinc-finger DNA-binding protein
Gene Aliases: 4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; HUMHOXY1; KMT8; KMT8A; MTB-ZF; PRDM2; RIZ; RIZ1; RIZ2; Znfpr1c1
UniProt ID: (Human) Q13029, (Rat) Q63755
Entrez Gene ID: (Human) 7799, (Mouse) 110593, (Rat) 313678
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity
sequence-specific DNA binding
metal ion binding
histone H3K9 trimethyltransferase activity
histone-lysine N-methyltransferase activity
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
determination of adult lifespan
methylation
positive regulation of transcription from RNA polymerase II promoter
response to estradiol
transcription, DNA-templated
histone lysine methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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