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Proteintech
PRICKLE1 Polyclonal Antibody
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Product Details
22589-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Chicken
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRICKLE1 Fusion Protein Ag18407 (321-580 aa encoded by BC114939)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AFQSARSRD SRRSVRMGKS SRSADQCRQS LLLSPALNYK FPGLSGNADD TLSRKLDDLS LSRQGTSFAS EEFWKGRVEQ ETPEDPEEWA DHEDYMTQLL LKFGDKSLFQ PQPNEMDIRA SEHWISDNMV KSKTELKQNN QSLASKKYQS DMYWAQSQDG LGDSAYGSHP GPASSRRLQE LELDHGASGY NHDETQWYED SLECLSDLKP EQSVRDSMDS LALSNITGAS VDGENKPRPS LYSLQNFEEM ETEDCEKMSN M (321-580 aa encoded by BC114939)
Target Information
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: prickle homolog 1; prickle like 1; prickle-like 1; Prickle-like protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1; unnamed protein product
Gene Aliases: 1110058P22Rik; AW215793; b2b019Clo; EPM1B; mpk1; Prickle; PRICKLE1; RILP
UniProt ID: (Human) Q96MT3, (Mouse) Q3U5C7
Entrez Gene ID: (Human) 144165, (Mouse) 106042
neural tube closure
tissue homeostasis
outflow tract morphogenesis
protein import into nucleus
apoptotic process
cytoskeleton organization
establishment or maintenance of cell polarity
epidermal growth factor receptor signaling pathway
axonogenesis
heart development
response to xenobiotic stimulus
organ morphogenesis
tissue development
gene expression
programmed cell death
Wnt signaling pathway
vesicle-mediated transport
dendrite development
cell migration
establishment of cell polarity
bone mineralization
embryonic limb morphogenesis
cytoskeleton-dependent intracellular transport
neuron projection development
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
limb morphogenesis
multicellular organism growth
embryonic nail plate morphogenesis
aorta development
post-anal tail morphogenesis
embryonic digit morphogenesis
cilium organization
establishment of protein localization
negative regulation of transcription, DNA-templated
neuron projection morphogenesis
response to electrical stimulus
cardiac muscle cell development
Wnt signaling pathway, planar cell polarity pathway
limb development
cilium morphogenesis
face morphogenesis
mesenchyme development
coronary vasculature development
eyelid development in camera-type eye
establishment of bipolar cell polarity involved in cell morphogenesis
cornea development in camera-type eye
renal tubule development
polarized secretion of basement membrane proteins in epithelium
tear secretion
basement membrane organization
extracellular matrix assembly
primitive streak formation
negative regulation of canonical Wnt signaling pathway
mitotic spindle assembly
cell-cell adhesion
regulation of postsynaptic density assembly
maintenance of postsynaptic density structure
focal adhesion disassembly
anterior visceral endoderm cell migration
neuron projection extension
embryonic brain development
negative regulation of cardiac muscle cell myoblast differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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