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Proteintech
PRICKLE1 Polyclonal Antibody, CoraLite® Plus 488
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FIGURE: 1 / 1
PRICKLE1 Antibody (CL488-22589) in Flow
1x10^6 HeLa cells were intracellularly stained with 0.8 µg CoraLite® Plus 488 Anti-Human PRICKLE1 (CL488-22589) (red), or 0.8 µg CoraLite® Plus 488-conjugated Rabbit IgG control Rabbit PolyAb (CL488-30000) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-22589
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRICKLE1 fusion protein Ag18407
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AFQSARSRD SRRSVRMGKS SRSADQCRQS LLLSPALNYK FPGLSGNADD TLSRKLDDLS LSRQGTSFAS EEFWKGRVEQ ETPEDPEEWA DHEDYMTQLL LKFGDKSLFQ PQPNEMDIRA SEHWISDNMV KSKTELKQNN QSLASKKYQS DMYWAQSQDG LGDSAYGSHP GPASSRRLQE LELDHGASGY NHDETQWYED SLECLSDLKP EQSVRDSMDS LALSNITGAS VDGENKPRPS LYSLQNFEEM ETEDCEKMSN M
Target Information
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: prickle homolog 1; prickle like 1; prickle-like 1; Prickle-like protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1
Gene Aliases: 1110058P22Rik; AW215793; b2b019Clo; EPM1B; mpk1; Prickle; PRICKLE1; RILP
UniProt ID: (Human) Q96MT3, (Mouse) Q3U5C7
Entrez Gene ID: (Human) 144165, (Mouse) 106042
neural tube closure
protein import into nucleus
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
aorta development
negative regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
coronary vasculature development
negative regulation of canonical Wnt signaling pathway
negative regulation of cardiac muscle cell myoblast differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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