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Product Details
12232-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRKACB Fusion Protein Ag2870 (1-257 aa encoded by BC016285)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNAATAKK GSEVESVKEF LAKAKEDFLK KWENPTQNNA GLEDFERKKT LGTGSFGRVM LVKHKATEQY YAMKILDKQK VVKLKQIEHT LNEKRILQAV NFPFLVRLEY AFKDNSNLYM VMEYVPGGEM FSHLRRIGRF SEPHARFYAA QIVLTFEYLH SLDLIYRDLK PENLLIDHQG YIQVTDFGFA KRVKGRTWTL CGTPEYLAPE IILSKGYNKA VDWWALGVLI YEMAAGYPPF FADQPIQIYE KIVSGKNF (1-257 aa encoded by BC016285)
Target Information
The catalytic subunit C-beta of PKA (PRKACB) is a member of the Ser/Thr protein kinase family (the PKA catalytic subunit consist of three gene products: C-alpha, C-beta, and C-gamma) and has been assigned to human chromosome region 1p36.1. PRKACB is derived from a gene distinct from C-alpha and shows tissue-specific expression. At the amino acid level C-alpha and C-beta showed 93% homology. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; protein kinase A catalytic subunit beta; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, beta
Gene Aliases: PKA C-beta; PKACB; PRKACB
UniProt ID: (Human) P22694, (Rat) P68182, (Mouse) P68181
Entrez Gene ID: (Human) 5567, (Rat) 293508, (Mouse) 18749
magnesium ion binding
protein serine/threonine kinase activity
cAMP-dependent protein kinase activity
protein binding
ATP binding
kinase activity
ubiquitin protein ligase binding
protein kinase A regulatory subunit binding
nucleotide binding
protein kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
neural tube closure
stimulatory C-type lectin receptor signaling pathway
renal water homeostasis
protein phosphorylation
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
blood coagulation
activation of protein kinase A activity
lipoprotein metabolic process
negative regulation of meiotic cell cycle
regulation of protein processing
cellular response to glucagon stimulus
response to clozapine
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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