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Proteintech
PRKACB Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
12232-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRKACB Fusion Protein Ag2870 (1-257 aa encoded by BC016285)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNAATAKK GSEVESVKEF LAKAKEDFLK KWENPTQNNA GLEDFERKKT LGTGSFGRVM LVKHKATEQY YAMKILDKQK VVKLKQIEHT LNEKRILQAV NFPFLVRLEY AFKDNSNLYM VMEYVPGGEM FSHLRRIGRF SEPHARFYAA QIVLTFEYLH SLDLIYRDLK PENLLIDHQG YIQVTDFGFA KRVKGRTWTL CGTPEYLAPE IILSKGYNKA VDWWALGVLI YEMAAGYPPF FADQPIQIYE KIVSGKNF (1-257 aa encoded by BC016285)
Target Information
The catalytic subunit C-beta of PKA (PRKACB) is a member of the Ser/Thr protein kinase family (the PKA catalytic subunit consist of three gene products: C-alpha, C-beta, and C-gamma) and has been assigned to human chromosome region 1p36.1. PRKACB is derived from a gene distinct from C-alpha and shows tissue-specific expression. At the amino acid level C-alpha and C-beta showed 93% homology. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP-dependent protein kinase C beta; Cbeta2 PKA; PKA C-beta; protein kinase A catalytic subunit beta; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, beta; unnamed protein product
Gene Aliases: CAFD2; CbPKA; PKA C-beta; PKACB
UniProt ID: (Human) P22694, (Mouse) P68181, (Rat) P68182
Entrez Gene ID: (Human) 5567, (Mouse) 18749, (Rat) 293508
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cAMP-dependent protein kinase activity
protein binding
ATP binding
potassium channel inhibitor activity
protein serine kinase activity
cyclic nucleotide-dependent protein kinase activity
ubiquitin protein ligase binding
protein kinase A regulatory subunit binding
neural tube closure
protein phosphorylation
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular response to nutrient levels
TORC1 signaling
negative regulation of smoothened signaling pathway
negative regulation of meiotic cell cycle
regulation of protein processing
negative regulation of TORC1 signaling
renal water homeostasis
signal transduction
positive regulation of insulin secretion
high-density lipoprotein particle assembly
vascular endothelial cell response to laminar fluid shear stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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