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Proteintech
PRKACB Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-12232
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRKACB fusion protein Ag2870
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MGNAATAKK GSEVESVKEF LAKAKEDFLK KWENPTQNNA GLEDFERKKT LGTGSFGRVM LVKHKATEQY YAMKILDKQK VVKLKQIEHT LNEKRILQAV NFPFLVRLEY AFKDNSNLYM VMEYVPGGEM FSHLRRIGRF SEPHARFYAA QIVLTFEYLH SLDLIYRDLK PENLLIDHQG YIQVTDFGFA KRVKGRTWTL CGTPEYLAPE IILSKGYNKA VDWWALGVLI YEMAAGYPPF FADQPIQIYE KIVSGKNF
Target Information
The catalytic subunit C-beta of PKA (PRKACB) is a member of the Ser/Thr protein kinase family (the PKA catalytic subunit consist of three gene products: C-alpha, C-beta, and C-gamma) and has been assigned to human chromosome region 1p36.1. PRKACB is derived from a gene distinct from C-alpha and shows tissue-specific expression. At the amino acid level C-alpha and C-beta showed 93% homology. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; protein kinase A catalytic subunit beta; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, beta; unnamed protein product
Gene Aliases: CAFD2; PKA C-beta; PKACB; PRKACB
UniProt ID: (Human) P22694, (Rat) P68182, (Mouse) P68181
Entrez Gene ID: (Human) 5567, (Rat) 293508, (Mouse) 18749
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cAMP-dependent protein kinase activity
protein binding
ATP binding
kinase activity
transferase activity
ubiquitin protein ligase binding
protein serine kinase activity
protein kinase A regulatory subunit binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
neural tube closure
renal water homeostasis
protein phosphorylation
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cellular response to nutrient levels
high-density lipoprotein particle assembly
TORC1 signaling
negative regulation of smoothened signaling pathway
regulation of protein processing
vascular endothelial cell response to laminar fluid shear stress
negative regulation of TORC1 signaling
negative regulation of meiotic cell cycle
response to clozapine
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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