JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
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Protein Aliases: Caveolae-associated protein 3; Cavin 3; Cavin-3; D3T-inducible gene 2 protein; DIG-2; Dithiolethione-inducible gene 2 protein; dithiolethione-inducible gene-2; HSRBC; PKC-delta binding protein; PRKCDBP; Protein kinase C delta-binding protein; protein kinase C, delta binding protein; sdr-elated gene product that binds to c-kinase; sdr-related gene product that binds to c-kinase; Serum deprivation response factor-related gene product that binds to C-kinase; SRBC
Gene Aliases: 3110015B12Rik; 6330514M23Rik; cavin-3; CAVIN3; DIG-2; Dig2; HSRBC; PRKCDBP; SRBC
Molecular Function: transcription factor