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Product Details
15186-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRL3 Fusion Protein Ag7249 (1-148 aa encoded by BC003105)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MARMNRPAP VEVSYKHMRF LITHNPTNAT LSTFIEDLKK YGATTVVRVC EVTYDKTPLE KDGITVVDWP FDDGAPPPGK VVEDWLSLVK AKFCEAPGSC VAVHCVAGLG RKRRGAINSK QLTYLEKYRP KQRLRFKDPH THKTRCCVM (1-148 aa encoded by BC003105 )
Target Information
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HPRL-3; potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; Protein tyrosine phosphatase type IVA 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3
Gene Aliases: PRL-3; PRL-R; PRL3; PTP4A3
UniProt ID: (Human) O75365
Entrez Gene ID: (Human) 11156
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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