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Bethyl Laboratories
PRMT10 Polyclonal Antibody
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FIGURE: 1 / 2
PRMT10 Antibody (A304-190A) in WB
Detection of human and rat PRMT10 by western blot. Samples: Whole cell lysate (50 µg) from 293T, HeLa, Jurkat, mouse TCMK-1, mouse NIH 3T3, and rat C6 cells. Antibodies: Affinity purified rabbit anti-PRMT10 antibody (Product # A304-190A) (lot A304-190A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A304-190A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 795 to 845 of Human Protein Arginine Methyltransferase 10.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein arginine methyltransferase 10 (putative); Protein arginine N-methyltransferase 10; Protein arginine N-methyltransferase 9; putative protein arginine N-methyltransferase 10; putative protein arginine N-methyltransferase 9
Gene Aliases: PRMT10; PRMT9; RGD1306157
UniProt ID: (Human) Q6P2P2
Entrez Gene ID: (Human) 90826, (Rat) 291947
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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