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Invitrogen
PRMT9 Polyclonal Antibody
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Product Details
PA5-65334
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PRMT9. Recombinant protein control fragment (Product #RP-106029).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VIAGTLGQVKP YSSVEKDQHR IALDLISEAN HFPKETLEFW LRHVEDESAM LQRPKSDKLW SIIILDVIEP SGLIQQEIME KAAISRCLLQ
Highest antigen sequence identity to the following orthologs - mouse 90%, rat 92%.
Target Information
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein arginine methyltransferase 10 (putative); Protein arginine N-methyltransferase 10; Protein arginine N-methyltransferase 9; putative protein arginine N-methyltransferase 10
Gene Aliases: PRMT10; PRMT9
UniProt ID: (Human) Q6P2P2
Entrez Gene ID: (Human) 90826
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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