This target displays homology in the following species: Cow: 90%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rabbit: 79%; Rat: 90%; Sheep: 90%
PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ames dwarf; Homeobox protein prophet of Pit-1; paired like homeodomain factor 1; paired like homeodomain factor 1-like; pituitary specific homeodomain factor; Pituitary-specific homeodomain factor; PROP-1; PROP1; prophet of Pit-1; prophet of Pit1 paired-like homeodomain transcription factor; prophet of Pit1, paired-like homeodomain transcription factor; prophet of POU1F1; transcription factor
Gene Aliases: BOS_7892; CPHD2; df; PROP-1; PROP1