Proteintech

PRPF6 Polyclonal Antibody

PRPF6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PRPF6 Antibody (23929-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis tissue slide using 23929-1-AP ( PRPF6 Antibody) at dilution of 1:50 (under 40x lens).

PRPF6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

23929-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRPF6 Fusion Protein Ag13817 (592-941 aa encoded by BC001666)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SLEALLQRA VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F (592-941 aa encoded by BC001666)

Target Information

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations.

Frontiers in genetics

Nazlamova L,Villa Vasquez SS,Lord J,Karthik V,Cheung MK,Lakowski J,Wheway G

Sat Oct 01 00:00:00 UTC 2022

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations.

Frontiers in genetics

Nazlamova L,Villa Vasquez SS,Lord J,Karthik V,Cheung MK,Lakowski J,Wheway G

Sat Oct 01 00:00:00 UTC 2022

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations.

Frontiers in genetics

Nazlamova L,Villa Vasquez SS,Lord J,Karthik V,Cheung MK,Lakowski J,Wheway G

Sat Oct 01 00:00:00 UTC 2022

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations.

Frontiers in genetics

Nazlamova L,Villa Vasquez SS,Lord J,Karthik V,Cheung MK,Lakowski J,Wheway G

Sat Oct 01 00:00:00 UTC 2022

A CRISPR and high-content imaging assay compliant with ACMG/AMP guidelines for clinical variant interpretation in ciliopathies.

Human genetics

Nazlamova L,Thomas NS,Cheung MK,Legebeke J,Lord J,Pengelly RJ,Tapper WJ,Wheway G

Thu Apr 01 00:00:00 UTC 2021

PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.

International journal of biological sciences

Liu W,Wang C,Wang S,Zeng K,Wei S,Sun N,Sun G,Wang M,Zou R,Liu W,Lin L,Song H,Jin Z,Zhao Y

Mon Jan 03 00:00:00 UTC 2022

Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.

Cancer science

Song H,Sun N,Lin L,Wei S,Zeng K,Liu W,Wang C,Zhong X,Wang M,Wang S,Zhou B,Lv C,Liu W,Zhao Y

Thu Oct 01 00:00:00 UTC 2020

Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.

Cancer science

Song H,Sun N,Lin L,Wei S,Zeng K,Liu W,Wang C,Zhong X,Wang M,Wang S,Zhou B,Lv C,Liu W,Zhao Y

Thu Oct 01 00:00:00 UTC 2020

Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma.

Cancer science

Song H,Sun N,Lin L,Wei S,Zeng K,Liu W,Wang C,Zhong X,Wang M,Wang S,Zhou B,Lv C,Liu W,Zhao Y

Thu Oct 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: androgen receptor N-terminal domain transactivating protein-1; Androgen receptor N-terminal domain-transactivating protein 1; ANT-1; p102 U5 small nuclear ribonucleoprotein particle-binding protein; Pre-mRNA-processing factor 6; PRP6 homolog; PRP6 pre-mRNA processing factor 6 homolog; putative mitochondrial outer membrane protein import receptor; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein

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Gene Aliases: 1190003A07Rik; 2610031L17Rik; ANT-1; ANT1; C20orf14; hPrp6; Prp6; PRPF6; RP60; SNRNP102; TOM; U5-102K

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UniProt ID: (Human) O94906, (Mouse) Q91YR7

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Entrez Gene ID: (Human) 24148, (Mouse) 68879

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Function(s)

transcription coactivator activity RNA binding protein binding ribonucleoprotein complex binding poly(A) RNA binding androgen receptor binding RNA splicing factor

Process(es)

spliceosomal tri-snRNP complex assembly spliceosomal complex assembly RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA localization RNA splicing positive regulation of transcription from RNA polymerase II promoter RNA processing mRNA processing

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PRPF6 Polyclonal Antibody

PRPF6 Antibody (23929-1-AP) in IHC (P)

Product Details

23929-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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