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Proteintech
PRPS2 Polyclonal Antibody
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Product Details
27024-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRPS2 Fusion Protein Ag25785 (143-273 aa encoded by BC119662)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IPVDNLYAE PAVLQWIREN IAEWKNCIIV SPDAGGAKRV TSIADRLNVE FALIHKERKK ANEVDRMVLV GDVKDRVAIL VDDMADTCGT ICHAADKLLS AGATKVYAIL THGIFSGPAI SRINNAAFEA VV (143-273 aa encoded by BC119662)
Target Information
The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase II; PPRibP; PPRibP synthetase; PRS-II; ribose-phosphate diphosphokinase 2; Ribose-phosphate pyrophosphokinase 2; testicular secretory protein Li 41
Gene Aliases: 2610101M19Rik; AA589463; AI464149; Prps-2; PRPS2; PRSII
UniProt ID: (Human) P11908, (Mouse) Q9CS42
Entrez Gene ID: (Human) 5634, (Mouse) 110639
magnesium ion binding
ribose phosphate diphosphokinase activity
protein binding
ATP binding
kinase activity
identical protein binding
protein homodimerization activity
nucleotide binding
AMP binding
transferase activity
GDP binding
carbohydrate binding
ADP binding
metal ion binding
nucleotide kinase
5-phosphoribose 1-diphosphate biosynthetic process
nucleobase-containing compound metabolic process
nucleoside metabolic process
ribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
phosphorylation
AMP biosynthetic process
ribose phosphate metabolic process
cellular biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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