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Invitrogen
PRSS21 Polyclonal Antibody
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Product Details
PA5-107225
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N terminal region of human PRSS21
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.4, with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Sequence homology: Guinea Pig: 83%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%
Target Information
PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.21; Eosinophil serine protease 1; ESP-1; protease, serine, 21 (testisin); Serine protease 21; serine protease from eosinophils; TEST1testisin; Testisin
Gene Aliases: ESP-1; ESP1; PRSS21; TEST1; TESTISIN; UNQ266/PRO303
UniProt ID: (Human) Q9Y6M0
Entrez Gene ID: (Human) 10942
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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