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Product Details
10801-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSAP Fusion Protein Ag1194 (1-320 aa encoded by BC001503)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This PSAP antibody (10801-1-AP) is expected to recognize both saposin A and B.
Immunogen sequence: MYALFLLAS LLGAALAGPV LGLKECTRGS AVWCQNVKTA SDCGAVKHCL QTVWNKPTVK SLPCDICKDV VTAAGDMLKD NATEEEILVY LEKTCDWLPK PNMSASCKEI VDSYLPVILD IIKGEMSRPG EVCSALNLCE SLQKHLAELN HQKQLESNKI PELDMTEVVA PFMANIPLLL YPQDGPRSKP QPKDNGDVCQ DCIQMVTDIQ TAVRTNSTFV QALVEHVKEE CDRLGPGMAD ICKNYISQYS EIAIQMMMHM QPKEICALVG FCDEVKEMPM QTLVPAKVAS KNVIPALELV EPIKKHEVPA KSDVYCEVCE F (1-320 aa encoded by BC001503)
Target Information
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Proactivator polypeptide; Prosaposin; sphingolipid activator protein-1
Gene Aliases: GLBA; PSAP; SAP1
UniProt ID: (Human) P07602
Entrez Gene ID: (Human) 5660
platelet degranulation
glycosphingolipid metabolic process
lipid transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of autophagy
regulation of lipid metabolic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
prostate gland growth
epithelial cell differentiation involved in prostate gland development
cellular response to organic substance
negative regulation of hydrogen peroxide-induced cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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