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Proteintech
PSAP Polyclonal Antibody
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Product Details
18396-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSAP Fusion Protein Ag13263 (61-143 aa encoded by BC001503)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody should recognize saposin A.
Immunogen sequence: LPCDICKDV VTAAGDMLKD NATEEEILVY LEKTCDWLPK PNMSASCKEI VDSYLPVILD IIKGEMSRPG EVCSALNLCE SLQK (61-143 aa encoded by BC001503)
Target Information
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: co-beta glucosidase precursor; precursor of saposins; Proactivator polypeptide; Prosaposin; PSAP; saposin-A; saposin-B; saposin-C; saposin-D; SGP-1; snoRNA MBII-198; sphingolipid activator protein-1; sphingolipid activator protein-2; Sulfated glycoprotein 1; unnamed protein product
Gene Aliases: AI037048; GLBA; PARK24; PSAP; PSAPD; SAP1; SAP2; SGP-1; Sgp1
UniProt ID: (Human) P07602, (Mouse) Q61207
Entrez Gene ID: (Human) 5660, (Mouse) 19156
protease binding
protein binding
phospholipid binding
enzyme activator activity
lipid binding
identical protein binding
protein homodimerization activity
scaffold protein binding
ganglioside GM1 binding
ganglioside GM2 binding
ganglioside GM3 binding
ganglioside GT1b binding
ganglioside GP1c binding
G-protein coupled receptor binding
scaffold/adaptor protein
lipid metabolic process
sphingolipid metabolic process
lysosomal transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of autophagy
regulation of lipid metabolic process
prostate gland growth
epithelial cell differentiation involved in prostate gland development
positive regulation of beta-galactosidase activity
ganglioside GM1 transport to membrane
regulation of MAPK cascade
positive regulation of MAPK cascade
developmental growth
cellular response to organic substance
negative regulation of hydrogen peroxide-induced cell death
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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