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Product Details
18423-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSAP Fusion Protein Ag13266 (406-487 aa encoded by BC001503)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This antibody should recognize saposin D.
Immunogen sequence: GGFCEVCKK LVGYLDRNLE KNSTKQEILA ALEKGCSFLP DPYQKQCDQF VAEYEPVLIE ILVEVMDPSF VCLKIGACPS AHK (406-487 aa encoded by BC001503)
Target Information
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1 activator; Cerebroside sulfate activator; Co-beta-glucosidase; Component C; CSAct; Dispersin; Glucosylceramidase activator; Proactivator polypeptide; Prosaposin; Protein A; Protein C; SAP-1; SAP-2; Saposin-A; Saposin-B; Saposin-B-Val; Saposin-C; Saposin-D; SGP-1; snoRNA MBII-198; Sphingolipid activator protein 1; Sphingolipid activator protein 2; sphingolipid activator protein-1; Sulfated glycoprotein 1; Sulfatide/GM1 activator
Gene Aliases: AI037048; GLBA; PSAP; SAP1; SGP-1; Sgp1
UniProt ID: (Human) P07602, (Mouse) Q61207
Entrez Gene ID: (Human) 5660, (Mouse) 19156
Molecular Function:
scaffold/adaptor protein
platelet degranulation
glycosphingolipid metabolic process
lipid transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of autophagy
regulation of lipid metabolic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
prostate gland growth
epithelial cell differentiation involved in prostate gland development
cellular response to organic substance
negative regulation of hydrogen peroxide-induced cell death
lipid metabolic process
sphingolipid metabolic process
regulation of MAPK cascade
developmental growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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