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Product Details
PA5-110226
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human PSAP (NP_0027691)
Conjugate
Form
Liquid
Concentration
1.24 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855637
Product Specific Information
Immunogen sequence: KEMPMQTLVP AKVASKNVIP ALELVEPIKK HEVPAKSDVY CEVCEFLVKE VTKLIDNNKT EKEILDAFDK MCSKLPKSLS EECQEVVDTY GSSILSILLE EVSPELVCSM LHLCSGTRLP ALTVHVTQPK DGGFCEVCKK LVGYLDRNLE KNSTKQEILA ALEKGCSFLP DPYQKQCDQF VAEYEPVLIE ILVEVMDPSF VCLKIGACPS AHKPLLGTEK CIWGPSYWCQ NTETAAQCNA VEHCKRHVWN
Target Information
PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Proactivator polypeptide; Prosaposin; prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); SGP-1; snoRNA MBII-198; sphingolipid activator protein-1; Sulfated glycoprotein 1
Gene Aliases: AI037048; GLBA; PSAP; SAP1; SGP-1; Sgp1; SGP1A
UniProt ID: (Human) P07602, (Rat) Q64190, (Mouse) Q61207
Entrez Gene ID: (Human) 5660, (Rat) 25524, (Mouse) 19156
platelet degranulation
glycosphingolipid metabolic process
lipid transport
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
regulation of autophagy
regulation of lipid metabolic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
prostate gland growth
epithelial cell differentiation involved in prostate gland development
cellular response to organic substance
negative regulation of hydrogen peroxide-induced cell death
sphingolipid metabolic process
regulation of MAPK cascade
glycolipid transport
developmental growth
lipid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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