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      View (2) other PSAP antibodies

      Invitrogen

      PSAP Monoclonal Antibody (4D5F4)

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      Catalog #:MA5-17159

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      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) 1:200 - 1:400
      Immunocytochemistry (ICC) 1:50-1:500
      Immunofluorescence (IF) 1:50 - 500
      Immunohistochemistry (IHC) 1:200 - 1:1000
      Western Blot (WB) 1:500 - 1:2000
      Tested Species reactivity Human
      Host / Isotype Mouse / IgG1
      Class Monoclonal
      Type Antibody
      Clone 4D5F4
      Immunogen Purified recombinant fragment of human PSAP (amino acids: 325-524 ) expressed in E. Coli.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification purified
      Storage buffer PBS with 0.5% proprietary stabilizer
      Contains 0.05% sodium azide
      Storage conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
      RRID AB_2538630

      Product Specific Information

      MA5-17159 targets PSAP in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.

      The MA5-17159 immunogen is purified recombinant fragment of human PSAP (amino acids: 325-524 ) expressed in E. Coli.

      MA5-17159 detects PSAP which has a predicted molecular weight of approximately 58.1kDa.

      Background/Target Information

      This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Bioinformatics

      Protein Aliases: Proactivator polypeptide; Prosaposin; sphingolipid activator protein-1

      Gene Aliases: GLBA; PSAP; SAP1

      UniProt ID: (Human) P07602

      Entrez Gene ID: (Human) 5660

      Suggested Secondary Antibodies

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