Proteintech

PSF2 Polyclonal Antibody

PSF2 Antibody in Immunocytochemistry (ICC/IF)

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PSF2 Antibody (16247-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 16247-1-AP (PSF2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

PSF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

16247-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PSF2 Fusion Protein Ag9180 (1-185 aa encoded by BC010164)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDAAEVEFL AEKELVTIIP NFSLDKIYLI GGDLGPFNPG LPVEVPLWLA INLKQRQKCR LLPPEWMDVE KLEKMRDHER KEETFTPMPS PYYMELTKLL LNHASDNIPK ADEIRTLVKD MWDTRIAKLR VSADSFVRQQ EAHAKLDNLT LMEINTSGTF LTQALNHMYK LRTNLQPLES TQSQDF (1-185 aa encoded by B C010164)

Target Information

The yeast heterotetrameric GINS complex is made up of Sld5, Psf1, Psf2, and Psf3. The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 ). See GINS1 for additional information about the GINS complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.

Nature communications

Xu X,Chang CW,Li M,Omabe K,Le N,Chen YH,Liang F,Liu Y

Sat Mar 04 00:00:00 UTC 2023

Identification of GINS2 prognostic potential and involvement in immune cell infiltration in hepatocellular carcinoma.

Journal of Cancer

Li Z,Song G,Guo D,Zhou Z,Qiu C,Xiao C,Wang X,Wang Y

Tue Jan 25 00:00:00 UTC 2022

Identification of GINS2 prognostic potential and involvement in immune cell infiltration in hepatocellular carcinoma.

Journal of Cancer

Li Z,Song G,Guo D,Zhou Z,Qiu C,Xiao C,Wang X,Wang Y

Tue Jan 25 00:00:00 UTC 2022

Increased replication origin firing links replication stress to whole chromosomal instability in human cancer.

Cell reports

Böhly N,Schmidt AK,Zhang X,Slusarenko BO,Hennecke M,Kschischo M,Bastians H

Tue Dec 13 00:00:00 UTC 2022

Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.

JCI insight

Conte MI,Poli MC,Taglialatela A,Leuzzi G,Chinn IK,Salinas SA,Rey-Jurado E,Olivares N,Veramendi-Espinoza L,Ciccia A,Lupski JR,Aldave Becerra JC,Mace EM,Orange JS

Tue Nov 08 00:00:00 UTC 2022

LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components.

The Journal of cell biology

Fan Y,Köberlin MS,Ratnayeke N,Liu C,Deshpande M,Gerhardt J,Meyer T

Mon Aug 02 00:00:00 UTC 2021

Embryonic expression of GINS members in the development of the mammalian nervous system.

Neurochemistry international

Jia W,Hsieh HY,Kidoya H,Takakura N

Tue Oct 01 00:00:00 UTC 2019

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality.

Oncogene

Szmyd R,Niska-Blakie J,Diril MK,Renck Nunes P,Tzelepis K,Lacroix A,van Hul N,Deng LW,Matos J,Dreesen O,Bisteau X,Kaldis P

Fri Feb 01 00:00:00 UTC 2019

TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.

The Journal of biological chemistry

Xu X,Wang JT,Li M,Liu Y

Fri Oct 21 00:00:00 UTC 2016

TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin.

The Journal of biological chemistry

Xu X,Wang JT,Li M,Liu Y

Fri Oct 21 00:00:00 UTC 2016

A role for USP7 in DNA replication.

Molecular and cellular biology

Jagannathan M,Nguyen T,Gallo D,Luthra N,Brown GW,Saridakis V,Frappier L

Wed Jan 01 00:00:00 UTC 2014

A role for USP7 in DNA replication.

Molecular and cellular biology

Jagannathan M,Nguyen T,Gallo D,Luthra N,Brown GW,Saridakis V,Frappier L

Wed Jan 01 00:00:00 UTC 2014

Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.

Cell reports

Wang JT,Xu X,Alontaga AY,Chen Y,Liu Y

Thu May 08 00:00:00 UTC 2014

Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction.

Cell reports

Wang JT,Xu X,Alontaga AY,Chen Y,Liu Y

Thu May 08 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: DNA replication complex GINS protein PSF2; GINS complex subunit 2; GINS complex subunit 2 (Psf2 homolog)

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Gene Aliases: 2210013I18Rik; 4833427B12Rik; AI323585; CGI-122; DC5; GINS2; HSPC037; Pfs2; PSF2; RGD1311055

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UniProt ID: (Human) Q9Y248, (Mouse) Q9D600

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Entrez Gene ID: (Human) 51659, (Mouse) 272551, (Rat) 292058

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Function(s)

protein binding 3'-5' DNA helicase activity molecular_function DNA metabolism protein nucleic acid metabolism protein

Process(es)

double-strand break repair via break-induced replication DNA strand elongation involved in DNA replication DNA duplex unwinding mitotic DNA replication initiation DNA replication biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PSF2 Polyclonal Antibody

PSF2 Antibody (16247-1-AP) in ICC/IF

Product Details

16247-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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