Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Protein Aliases: CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; PC4 and SFRS1-interacting protein; transcriptional coactivator p52/p75; Transcriptional coactivator p75/p52
Gene Aliases: DFS70; LEDGF; p52; p75; PAIP; PSIP1; PSIP2
UniProt ID: (Human) O75475
Entrez Gene ID: (Human) 11168