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Invitrogen
PSMA4 Polyclonal Antibody
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FIGURE: 1 / 2
PSMA4 Antibody (PA5-144665) in IHC (P)
Immunohistochemistry of PSMA4 in paraffin-embedded rat kidney tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with PSMA4 polyclonal antibody (Product # PA5-144665) with a dilution of 1:800 for 1 hour at room temperature... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-144665
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human PSMA4 aa 62-261.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive control: Jurkat cell lysate, Hela cell lysate, K562 cell lysate, U937 cell lysate, rat testis tissue lysate, mouse cerebellum tissue lysate, human placenta tissue lysate, rat kidney tissue.
Predicted band size: 29 kDa
Subcellular Location: Cytoplasm Nucleus Cytoplasm, P-body.
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-3; macropain subunit C9; MGC111191; MGC12467; MGC24813; multicatalytic endopeptidase complex subunit C9; multicatalytic proteinase subunit L; proteasome (prosome, macropain) subunit, alpha type 4; proteasome (prosome, macropain) subunit, alpha type, 4; proteasome alpha 4 subunit; proteasome component C9; proteasome subunit alpha 4; proteasome subunit alpha-3; proteasome subunit alpha3; proteasome subunit HC9; proteasome subunit L; PSMA 4; unnamed protein product
Gene Aliases: C9; HC9; HsT17706; PSC9
UniProt ID: (Human) P25789, (Rat) P21670, (Mouse) Q9R1P0
Entrez Gene ID: (Human) 5685, (Rat) 29671, (Mouse) 26441
ubiquitin-dependent protein catabolic process
response to oxidative stress
proteasomal protein catabolic process
protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
immune system process
DNA repair
apoptotic process
cellular response to DNA damage stimulus
spermatogenesis
proteasomal ubiquitin-independent protein catabolic process
sperm motility
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
response to interferon-gamma
CD8-positive, alpha-beta T cell differentiation
thymic T cell selection
T-helper 1 cell differentiation
negative regulation of regulatory T cell differentiation
meiotic cell cycle
cellular response to type I interferon
T-helper 17 cell differentiation
CD8-positive, alpha-beta T cell homeostasis
regulation of G1/S transition of mitotic cell cycle
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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