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Proteintech
PSMB6 Polyclonal Antibody
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Product Details
11684-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSMB6 Fusion Protein Ag2296 (1-239 aa encoded by BC000835)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAATLLAAR GAGPAPAWGP EAFTPDWESR EVSTGTTIMA VQFDGGVVLG ADSRTTTGSY IANRVTDKLT PIHDRIFCCR SGSAADTQAV ADAVTYQLGF HSIELNEPPL VHTAASLFKE MCYRYREDLM AGIIIAGWDP QEGGQVYSVP MGGMMVRQSF AIGGSGSSYI YGYVDATYRE GMTKEECLQF TANALALAME RDGSSGGVIR LAAIAESGVE RQVLLGDQIP KFAVATLPPA (1-239 aa encoded by BC000835)
Target Information
Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelmane's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta-1; Low molecular mass protein 19; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; proteasome (prosome, macropain) subunit, beta type, 6; proteasome beta 6 subunit; proteasome catalytic subunit 1; Proteasome chain 5; Proteasome delta chain; proteasome subunit beta 6; Proteasome subunit beta type-6; Proteasome subunit beta-1; proteasome subunit beta1; proteasome subunit delta; Proteasome subunit Y; PSMB6; PSY large multifunctional protease Y; RP23-122P1.4; subunit 2; unnamed protein product
Gene Aliases: DELTA; Lmp19; LMPY; Mpnd; PSMB6; Psmb6l; Y
UniProt ID: (Human) P28072, (Rat) P28073, (Mouse) Q60692
Entrez Gene ID: (Human) 5694, (Rat) 29666, (Mouse) 19175
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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