FIGURE: 1 / 3
Recommended positive controls: A431, Molt-4, Raji.
Predicted reactivity: Mouse (94%), Rat (94%), Japanese Medaka (80%), Xenopus laevis (83%), Dog (91%), Pig (93%), Sheep (93%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAAP-57C1.3; large multifunctional protease 7; low molecular mass polypeptide 7; Low molecular mass protein 7; low molecular weight protein 7; Macropain subunit C13; MC13 (LMP7); MGC1491; Multicatalytic endopeptidase complex subunit C13; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; protease component C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome catalytic subunit 3i; Proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta type 8; Proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit MC13; proteasome subunit Y2; proteasome-related gene 7; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit; Really interesting new gene 10 protein
Gene Aliases: ALDD; D6S216; D6S216E; JMP; Lmp-7; LMP7; Mc13; NKJO; PSMB5i; PSMB8; RING10; Y2
Molecular Function: protease