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Proteintech
PSMD2 Polyclonal Antibody
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Product Details
14748-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSMD2 Fusion Protein Ag6484 (561-908 aa encoded by BC002368)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GLGLNHLGK GEAIEAILAA LEVVSEPFRS FANTLVDVCA YAGSGNVLKV QQLLHICSEH FDSKEKEEDK DKKEKKDKDK KEAPADMGAH QGVAVLGIAL IAMGEEIGAE MALRTFGHLL RYGEPTLRRA VPLALALISV SNPRLNILDT LSKFSHDADP EVSYNSIFAM GMVGSGTNNA RLAAMLRQLA QYHAKDPNNL FMVRLAQGLT HLGKGTLTLC PYHSDRQLMS QVAVAGLLTV LVSFLDVRNI ILGKSHYVLY GLVAAMQPRM LVTFDEELRP LPVSVRVGQA VDVVGQAGKP KTITGFQTHT TPVLLAHGER AELATEEFLP VTPILEGFVI LRKNPNYDL (561-908 aa encoded by BC002368)
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; F23F1.8; MGC14274; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Protein 55.11; testis expressed gene 190; TNFR-associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2
Gene Aliases: 9430095H01Rik; AA407121; P97; PSMD2; RPN1; S2; TEG-190; Tex190; TRAP2
UniProt ID: (Human) Q13200, (Rat) Q4FZT9, (Mouse) Q8VDM4
Entrez Gene ID: (Human) 5708, (Rat) 287984, (Mouse) 21762
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
regulation of protein catabolic process
regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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